Synergy, antagonism, and scientific process.
نویسندگان
چکیده
منابع مشابه
Synergy, antagonism, and scientific process.
withdrew a previously published paper in which the authors had reported marked synergistic effects of several environmental chemicals on the activation of the estrogen receptor in a yeast reporter system (1). The possibility of synergistic interactions between weakly estrogenic chemicals found in the environment has very important mechanistic and public health implications. In their Science pap...
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Screening in mixtures is a common approach for increasing the efficiency of high-throughput screening. Here we investigate how the "compound load" of mixtures influences promiscuous aggregate-based inhibition. We screened 764 molecules individually and in mixtures of 10 at 5 miccroM each, comparing the observed inhibition of the mixtures to that predicted from single-compound results. Synergist...
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CC-BY 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Abstract 1 Although drug combinations have proven efficacious in a variety of diseases, the design of such 2 regimens often involves extensive experimental screening due to the myriad choice of drugs and 3 doses. To address these challenges, we...
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In public health there is a growing appreciation for the advantage of the additive scale to better understand the impacts of factors involved in a health event. It is necessary to always remember that the concept of statistical interaction is scale dependent. In the causal relationship between a response and the presence of two or more factors, the concepts interaction, synergy and antagonism a...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1997
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.97105784